Hyaluronan molecular weight distribution is associated with the risk of knee osteoarthritis progression
نویسندگان
چکیده
منابع مشابه
Knee osteoarthritis diagnosis, treatment and associated factors of progression: Part II
Diagnosis of knee osteoarthritis can be confirmed based on clinical and/or radiological features. The potential of a progressive disease can be prevented or decreased by earlier recognition and correction of associated factors. Obesity and alignment especially varus malalignment are recognized factors of a progressive disease. Both nonpharmalogical as well as pharmacological modalities of treat...
متن کاملPrevious Pregnancies and the Subsequent Risk of Knee Osteoarthritis
Background: Osteoarthritis of the knee is a major problem and one of the most causes of disability in the elderly. Woman tending to have more frequent and more severe evidence of knee osteoarthritis. Because of the possibility, that hormonal changes may influence the disease, the present study was designed to investigate the association between pregnancies and osteoarthritis of the knee. Metho...
متن کامل(Orthovisc) in osteoarthritis of the knee: a randomized, controlled, multicenter Clinical effects of intraarticular injection of high molecular weight hyaluronan
Objective. To evaluate the efficacy and safety of injection of high molecular weight (HMW) hyaluronan (Orthovisc®) in patients with mild, moderate, and severe knee osteoarthritis (OA). Methods. A randomized, arthrocentesis-controlled, multicenter trial. Patients (n = 372) were randomized to 4 weekly HMW hyaluronan injections (O4, n = 128), 3 weekly HMW hyaluronan injections followed by one arth...
متن کاملHyaluronan for knee osteoarthritis: an updated meta-analysis of trials with low risk of bias
BACKGROUND The effectiveness of intra-articular hyaluronic acid (IAHA) injection for knee osteoarthritis (KOA) is debated. OBJECTIVES To evaluate the effect of IAHA for patients with KOA by analysing data from trials of IAHA versus placebo with low risk of bias, to provide the highest level of evidence. METHODS A systematic review and meta-analysis was conducted. Randomised controlled trial...
متن کاملknee osteoarthritis diagnosis, treatment and associated factors of progression: part ii
diagnosis of knee osteoarthritis can be confirmed based on clinical and/or radiological features. the potential of a progressive disease can be prevented or decreased by earlier recognition and correction of associated factors. obesity and alignment especially varus malalignment are recognized factors of a progressive disease. both nonpharmalogical as well as pharmacological modalities of treat...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2015
ISSN: 1063-4584
DOI: 10.1016/j.joca.2014.09.017